Piperazine → HCID 21492787, compound

HRID 1973142Notes

Reaction equation

HRID 1973142 reaction equation
Cl[C:2]1[N:6]2[C:7]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:8]=3[C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)=[N:10][CH:11]([CH2:12][CH3:13])[C:5]2=[N:4][N:3]=1.[NH:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[Cl:24][C:21]1[CH:22]=[CH:23][C:7]2[N:6]3[C:2]([N:25]4[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]4)=[N:3][N:4]=[C:5]3[CH:11]([CH2:12][CH3:13])[N:10]=[C:9]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)[C:8]=2[CH:20]=1

Participants

3

Reactant 2

HCID 4837PiperazineHCID 21492830HCID 21492830, compound

Product 1

HCID 21492787HCID 21492787, compound

Procedure

In the manner given in Example 1, 1,8-dichloro-4-ethyl-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with piperazine to give 8-chloro-4-ethyl-1-piperazino-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-b911d79a2adf481fb22d677a49b6bf35
Source dataset
uspto-grants-1976_12
Patent number
US03996230

Reaction notes

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