Piperazine, 1-propyl-, hydrochloride (1:2) → HCID 21492829, compound

HRID 1973143Notes

Reaction equation

HRID 1973143 reaction equation
Br[C:2]1[N:6]2[C:7]3[CH:21]=[C:20]([F:22])[C:19]([Br:23])=[CH:18][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.[CH2:24]([N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)[CH2:25][CH3:26]>>[Br:23][C:19]1[C:20]([F:22])=[CH:21][C:7]2[N:6]3[C:2]([N:30]4[CH2:31][CH2:32][N:27]([CH2:24][CH2:25][CH3:26])[CH2:28][CH2:29]4)=[N:3][N:4]=[C:5]3[CH2:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[C:8]=2[CH:18]=1

Participants

3

Reactant 2

HCID 415812Piperazine, 1-propyl-, hydrochloride (1:2)HCID 21492808HCID 21492808, compound

Product 1

HCID 21492829HCID 21492829, compound

Procedure

In the manner given in Example 1, 1,8-dibromo-9-fluoro-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with excess 1-propylpiperazine to give 8-bromo-9-fluoro-1-(4-propylpiperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-c81a529a578f4906998273348f88aab7
Source dataset
uspto-grants-1976_12
Patent number
US03996230

Reaction notes

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