HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine, 1-propyl-, hydrochloride (1:2) → 8-bromo-9-fluoro-1-(4-propylpiperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine, 1-propyl-, hydrochloride (1:2) | HCID 415812 | — |
| Reactant | HCID 21492808 | HCID 21492808 | — |
| Product | 8-bromo-9-fluoro-1-(4-propylpiperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 21492829 | — |
Reaction Steps
In the manner given in Example 1, 1,8-dibromo-9-fluoro-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with excess 1-propylpiperazine to give 8-bromo-9-fluoro-1-(4-propylpiperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996230 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-c81a529a578f4906998273348f88aab7 |
| Source note | uspto-grants-1976_12 |