1-Methylpiperazine → HCID 21492817, compound

HRID 1973144Notes

Reaction equation

HRID 1973144 reaction equation
Br[C:2]1[N:6]2[C:7]3[CH:21]=[C:20]([Br:22])[C:19]([Cl:23])=[CH:18][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.[CH3:24][N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[Br:22][C:20]1[C:19]([Cl:23])=[CH:18][C:8]2[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]3[N:6]([C:2]([N:28]4[CH2:29][CH2:30][N:25]([CH3:24])[CH2:26][CH2:27]4)=[N:3][N:4]=3)[C:7]=2[CH:21]=1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 21492803HCID 21492803, compound

Product 1

HCID 21492817HCID 21492817, compound

Procedure

In the manner given in Example 1, 1,9-dibromo-8-chloro-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with 1-methylpiperazine to give 9-bromo-8-chloro-1-(4-methylpiperazino)-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-428d5644646f482ba19ecd15e2876147
Source dataset
uspto-grants-1976_12
Patent number
US03996230

Reaction notes

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