Piperazine → HCID 21492823, compound

HRID 1973146Notes

Reaction equation

Br[C:2]1[N:6]2[C:7]3[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][C:8]=3[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)=[N:10][CH2:11][C:5]2=[N:4][N:3]=1.[NH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[Br:22][C:19]1[CH:20]=[CH:21][C:7]2[N:6]3[C:2]([N:23]4[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]4)=[N:3][N:4]=[C:5]3[CH2:11][N:10]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=3)[C:8]=2[CH:18]=1

Participants

Reactant 2

HCID 4837Piperazine

HCID 12562520HCID 12562520, compound

Product 1

HCID 21492823HCID 21492823, compound

Procedure

In the manner given in Example 1, 1,8-dibromo-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine is heated with piperazine to give 8-bromo-1-piperazino-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record: ord-9fe6f9ed813f4a5e88d2551f4b3e1550
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03996230

Reaction notes

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