反应详情

A mixture of methyl salicylate (6.4 ml., 7.6 g., 0.05 mole), 2,2,2-trifluoroethyl trifluoromethanesulfonate (13.9 g., 0.06 mole), anhydrous potassium carbonate (13.8 g., 0.1 mole) and acetone (150 ml.) is heated under reflux with efficient stirring for three days. The product is filtered and the filtrate is concentrated to a small volume. It is diluted with cold water and the resulting precipitate is collected and washed successively with cold dilute sodium hydroxide solution and water. The desired material is recrystallized then from aqueous ethanol to afford white solid, m.p. 61-62.

1. temperatureis heated
2. temperatureunder reflux
3. filtrationThe product is filtered
4. concentrationthe filtrate is concentrated to a small volume
5. additionIt is diluted with cold water
6. customthe resulting precipitate is collected
7. washwashed successively with cold dilute sodium hydroxide solution and water
8. customThe desired material is recrystallized
9. customfrom aqueous ethanol to afford white solid, m.p. 61-62