HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1-(2,2,2-Trifluoroethoxy)-2-Naphthoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Methyl 1-(2,2,2-trifluoroethoxy)naphthalene-2-carboxylate | HCID 21493172 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-(2,2,2-Trifluoroethoxy)-2-Naphthoic Acid | HCID 21493153 | — |
Reaction Steps
A mixture of 10 g. (35 mmoles) of methyl 1-(2,2,2-trifluoroethoxy)-2-naphthoate, 2.9 g., (42 mmoles) of potassium hydroxide, 50 ml. of ethanol and 40 ml. of water is refluxed for one hour, chilled and acidified. The fluffy precipitate is collected, water washed, and air-dried. It is purified by recrystallization first from chloroform and then from aqueous alcohol, m.p. 171.5°-172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996280 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-7aeb48dd48134ebea64d7748f1e929a7 |
| Source note | uspto-grants-1976_12 |