HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(2,2,2-Trifluoroethoxy)-2-naphthoyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 1-(2,2,2-Trifluoroethoxy)-2-Naphthoic Acid | HCID 21493153 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | 1-(2,2,2-Trifluoroethoxy)-2-naphthoyl Chloride | HCID 21493150 | — |
Reaction Steps
A mixture of 10 g. (37 mmoles) of 1-(2,2,2-trifluoroethoxy)-2-naphthoic acid, 21.8 ml. (35.7 g., 300 mmoles) of purified thionyl chloride and 3 drops of dimethylformamide is refluxed for one hour. Excess thionyl chloride is removed in vacuo at water aspirator pressure while heating on a steam bath. Last traces of thionyl chloride are removed by vacuum distillation with added benzene. The product is 1-(2,2,2-trifluoroethoxy)-2-naphthoyl chloride according to infrared spectral measurement.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996280 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-afc3b72f7eb447d487f21eface9e9990 |
| Source note | uspto-grants-1976_12 |