反应详情

A mixture of 10 g. (37 mmoles) of 1-(2,2,2-trifluoroethoxy)-2-naphthoic acid, 21.8 ml. (35.7 g., 300 mmoles) of purified thionyl chloride and 3 drops of dimethylformamide is refluxed for one hour. Excess thionyl chloride is removed in vacuo at water aspirator pressure while heating on a steam bath. Last traces of thionyl chloride are removed by vacuum distillation with added benzene. The product is 1-(2,2,2-trifluoroethoxy)-2-naphthoyl chloride according to infrared spectral measurement.

1. additionA mixture of 10 g
2. customExcess thionyl chloride is removed in vacuo at water aspirator pressure
3. temperaturewhile heating on a steam bath
4. customLast traces of thionyl chloride are removed by vacuum distillation with added benzene