HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → Benzoyl chloride, 2,5-bis(2,2,2-trifluoroethoxy)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,5-bis(2,2,2-trifluoroethoxy)benzoic Acid | HCID 2736078 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Product | Benzoyl chloride, 2,5-bis(2,2,2-trifluoroethoxy)- | HCID 11427683 | — |
Reaction Steps
To 9.4 g. (30 mmoles) of 2,5-di-(2,2,2-trifluoroethoxy)benzoic acid are added 2 drops of dimethylformamide and 7.2 ml. (11.9 g., 100 mmoles) of purified thionyl chloride. The product is refluxed for 3 hours and excess thionyl chloride is removed in vacuo (steam bath/water aspirator pressure). Last traces of thionyl chloride are removed by similar vacuum distillation with added benzene. The product is 2,5-di-(2,2,2-trifluoroethoxy)benzoyl chloride according to infrared spectral measurement.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03996280 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-570dd2dc1f2b447b8c3adfa6a4823c9c |
| Source note | uspto-grants-1976_12 |