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HRID1973191

反应详情

EQUATION

反应方程式

HRID 1973191 的结构方程式

REACTANTS

反应物

2
结构：O=S(Cl)Cl
HCID24386

Thionyl chloride

Cl2OS

结构：O=C(O)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F
HCID2736078

2,5-bis(2,2,2-trifluoroethoxy)benzoic Acid

C11H8F6O4

PRODUCTS

生成物

1
结构：O=C(Cl)c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F
HCID11427683

Benzoyl chloride, 2,5-bis(2,2,2-trifluoroethoxy)-

C11H7ClF6O3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
催化剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

To 9.4 g. (30 mmoles) of 2,5-di-(2,2,2-trifluoroethoxy)benzoic acid are added 2 drops of dimethylformamide and 7.2 ml. (11.9 g., 100 mmoles) of purified thionyl chloride. The product is refluxed for 3 hours and excess thionyl chloride is removed in vacuo (steam bath/water aspirator pressure). Last traces of thionyl chloride are removed by similar vacuum distillation with added benzene. The product is 2,5-di-(2,2,2-trifluoroethoxy)benzoyl chloride according to infrared spectral measurement.

WORKUP

后处理

  1. temperatureThe product is refluxed for 3 hours
  2. customexcess thionyl chloride is removed in vacuo (steam bath/water aspirator pressure)
  3. customLast traces of thionyl chloride are removed by similar vacuum distillation with added benzene