Ethanol → 2-(2,2,2-Trifluoroethoxy)benzoic Acid Hydrazide

HRID 1973193Notes

Reaction equation

HRID 1973193 reaction equation
[F:1][C:2]([F:16])([F:15])[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7](OC)=[O:8].C(O)C.[NH2:20][NH2:21]>O>[F:1][C:2]([F:16])([F:15])[CH2:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[CH:11][C:6]=1[C:7]([NH:20][NH2:21])=[O:8]

Participants

5

Reactant 3

HCID 702EthanolHCID 9321HydrazineHCID 19622905Methyl 2-(2,2,2-trifluoroethoxy)benzoate

Product 1

HCID 681305812-(2,2,2-Trifluoroethoxy)benzoic Acid Hydrazide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Methyl 2-(2,2,2-trifluoroethoxy)benzoate (1.22 g. 5.2 mmole), ethanol (15 ml.) and 5 ml. of 95 per cent hydrazine (4.75 g., 158 mmole) are refluxed for two hours, cooled, diluted with water (100 ml.) and cooled. The white solid product, 2-(2,2,2-trifluoroethoxy)benzoic acid hydrazide is recrystallized from ethanol, m.p. 102°-104°.

Workup

  1. temperaturecooled
  2. temperaturecooled
  3. customThe white solid product, 2-(2,2,2-trifluoroethoxy)benzoic acid hydrazide is recrystallized from ethanol, m.p. 102°-104°

Sources & evidence

ORD record
ord-e71f53c5a9724943b613aded414047db
Source dataset
uspto-grants-1976_12
Patent number
US03996280

Reaction notes

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