N6-Methyladenine → N6-methyl-9-[3-(4-phenyl-piperazino)-propyl]-adenine

Participants

Reaction Steps

1.38 g (0.06 mole) of sodium are dissolved in 120 ml of isopropanol. 8.9 g (0.06 mole) of N6 -methyl-adenine are added to this solution, which is then heated under reflux for 10 minutes, cooled and 15.8 g (0.066 mole) of 3-(4-phenyl-piperazino)-propyl chloride in 30 ml of isopropanol are added thereto. This reaction mixture is heated under reflux for 6 hours. Thereafter, it is cooled, suction filtered and sodium chloride washed out from the residue with water. After washing with water and drying, the product is recrystallized from isopropanol. There are obtained 9.5 g (45% of theory) of N6 -methyl-9-[3-(4-phenyl-piperazino)-propyl]-adenine, which has a melting point of 162°-163° C.

Provenance & Evidence