反应详情

1.38 g (0.06 mole) of sodium are dissolved in 120 ml of isopropanol. 8.9 g (0.06 mole) of N6 -methyl-adenine are added to this solution, which is then heated under reflux for 10 minutes, cooled and 15.8 g (0.066 mole) of 3-(4-phenyl-piperazino)-propyl chloride in 30 ml of isopropanol are added thereto. This reaction mixture is heated under reflux for 6 hours. Thereafter, it is cooled, suction filtered and sodium chloride washed out from the residue with water. After washing with water and drying, the product is recrystallized from isopropanol. There are obtained 9.5 g (45% of theory) of N6 -methyl-9-[3-(4-phenyl-piperazino)-propyl]-adenine, which has a melting point of 162°-163° C.

1. temperatureis then heated
2. temperatureunder reflux for 10 minutes
3. temperaturecooled
4. temperatureThis reaction mixture is heated
5. temperatureunder reflux for 6 hours
6. temperatureThereafter, it is cooled
7. filtrationsuction filtered
8. washsodium chloride washed out from the residue with water
9. washAfter washing with water
10. customdrying
11. customthe product is recrystallized from isopropanol