Formaldehyde → HCID 21493487, compound

HRID 1973261Notes

Reaction equation

HRID 1973261 reaction equation
[O:1]=[C:2]1[C:6]2([CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[N:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:4][NH:3]1.[CH2:18]=O.[CH:20]1[CH:21]=[C:22]2[C:27]3=[C:28]([C:30]([NH:32][C:33](=[O:34])[C:26]3=[CH:25][CH:24]=[CH:23]2)=[O:31])[CH:29]=1>CN(C)C=O>[O:1]=[C:2]1[C:6]2([CH2:7][CH2:8][N:9]([CH2:18][N:32]3[C:33](=[O:34])[C:26]4[CH:25]=[CH:24][CH:23]=[C:22]5[C:27]=4[C:28](=[CH:29][CH:20]=[CH:21]5)[C:30]3=[O:31])[CH2:10][CH2:11]2)[N:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:4][NH:3]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 66491NaphthalimideHCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one

Product 1

HCID 21493487HCID 21493487, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

An equimolar mixture of 4-oxo-1-phenyl-1,3,8-triazaspiro-[4.5]decane, aqueous formaldehyde, and 1,8-naphthalimide is suspended in a small amount of dimethylformamide and the mixture is heated until dissolution is complete. The solution is allowed to stand at room temperature and the resulting precipitate is filtered off and dried to yield the titled compound.

Workup

  1. temperaturethe mixture is heated until dissolution
  2. customto stand at room temperature
  3. filtrationthe resulting precipitate is filtered off
  4. customdried

Sources & evidence

ORD record
ord-29bc76e927494be9aec6a824a8d76ecb
Source dataset
uspto-grants-1976_12
Patent number
US03996363

Reaction notes

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