反应详情

A mixture of 13.7 g. of methyl isonicotinate, 16.8 g. of cyclopropylmethyl ketone and 6 g. of sodium methoxide in 150 ml. of benzene is heated under reflux for 8 hours. The mixture is filtered and the collected solid is dissolved in water. The aqueous mixture is made weakly acidic with dilute hydrochloric acid and extracted with ether. The ethereal solution is dried over magnesium sulfate and concentrated under reduced pressure to give 1-cyclopropyl-3-(4-pyridyl)-1,3-propanedione as a mobile, yellow liquid, infra-red spectrum 6.15u (CHCl3, β-diketone.

1. additionA mixture of 13.7 g
2. temperatureunder reflux for 8 hours
3. filtrationThe mixture is filtered
4. dissolutionthe collected solid is dissolved in water
5. extractionextracted with ether
6. dry with materialThe ethereal solution is dried over magnesium sulfate
7. concentrationconcentrated under reduced pressure