4-(5-Cyclopropyl-1,2-oxazol-3-yl)pyridine → HCID 68142299, compound

HRID 1973350Notes

Reaction equation

HRID 1973350 reaction equation
[CH:1]1([C:4]2[O:8][N:7]=[C:6]([C:9]3[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=3)[CH:5]=2)[CH2:3][CH2:2]1.[H][H]>[Pt]=O.C(O)C>[NH2:7][C:6]([C:9]1[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=1)=[CH:5][C:4]([CH:1]1[CH2:2][CH2:3]1)=[O:8]

Participants

5

Reactant 2

HCID 123605774-(5-Cyclopropyl-1,2-oxazol-3-yl)pyridineHCID 178418361HCID 178418361, compound

Product 1

HCID 68142299HCID 68142299, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

A solution of 3 g. of 4-(5-cyclopropyl-3-isoxazolyl)pyridine in 50 ml. of ethanol is treated with 0.5 g. of platinum oxide and the mixture is treated with hydrogen on a Parr apparatus at 44 psi for 5 hours at 25° C. The mixture is filtered and the filtrate is evaporated to dryness under reduced pressure to give a semi-solid residue which is recrystallized from ethyl acetate to give light tan crystals, melting point 159°-166° C.

Workup

  1. filtrationThe mixture is filtered
  2. customthe filtrate is evaporated to dryness under reduced pressure
  3. customto give a semi-solid residue which
  4. customis recrystallized from ethyl acetate
  5. customto give light tan crystals, melting point 159°-166° C.

Sources & evidence

ORD record
ord-b983dbe6bf914c82a230c439a5bf25b6
Source dataset
uspto-grants-1976_12
Patent number
US03997530

Reaction notes

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