反应详情

A stirred mixture of 14.0 g. of methyl pyrazinoate, 16.8 g. of cyclopropylmethyl ketone, 6.0 g. of sodium methoxide and 200 ml. of benzene is heated under reflux for 5 hours. A 400 ml. volume of water is added to the mixture. The benzene phase is separated and the aqueous solution is made weakly acidic with dilute hydrochloric acid. A yellow solid precipitates, which is collected and recrystallized from hexane to give white crystals, m.p. 111°-112° C.

1. additionA stirred mixture of 14.0 g
2. temperatureunder reflux for 5 hours
3. customThe benzene phase is separated
4. customA yellow solid precipitates
5. customwhich is collected
6. customrecrystallized from hexane
7. customto give white crystals, m.p. 111°-112° C.