Sodium Carbonate → HCID 21491294, compound

HRID 1973367Notes

Reaction equation

HRID 1973367 reaction equation
[Cl:1][C:2]1[C:3]([C:14]([O:16]CC)=[O:15])=[N:4][C:5]2[C:10]([N:11]=1)=[CH:9][C:8]([CH3:12])=[C:7]([CH3:13])[CH:6]=2.C(=O)([O-])[O-].[Na+].[Na+]>CO.O>[Cl:1][C:2]1[C:3]([C:14]([OH:16])=[O:15])=[N:4][C:5]2[C:10]([N:11]=1)=[CH:9][C:8]([CH3:12])=[C:7]([CH3:13])[CH:6]=2

Participants

5

Reactant 2

HCID 10340Sodium CarbonateHCID 12283437HCID 12283437, compound

Product 1

HCID 21491294HCID 21491294, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3Chloro-6,7-dimethyl-2-quinoxalinecarboxylic acid, ethyl ester (14.5 g) and sodium carbonate (3.2 g) in methanol (300 ml) and water (75 ml) were heated under reflux for 2 hours. The methanol was distilled off and the aqueous solution was acidified with dilute hydrochloric acid. The solid was collected, dried and crystallised from a mixture of ethyl acetate and light petroleum (b.p. 60°-80°). It had m.p. 146.5°-148.5° (d) (75%).

Workup

  1. temperatureunder reflux for 2 hours
  2. distillationThe methanol was distilled off
  3. customThe solid was collected
  4. customdried
  5. customcrystallised from a mixture of ethyl acetate and light petroleum (b.p. 60°-80°)

Sources & evidence

ORD record
ord-de7b7092453f49718d1f5a95eb824c16
Source dataset
uspto-grants-1976_12
Patent number
US03997535

Reaction notes

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