Sodium Carbonate → HCID 21491294, compound

Participants

Reaction Steps

3Chloro-6,7-dimethyl-2-quinoxalinecarboxylic acid, ethyl ester (14.5 g) and sodium carbonate (3.2 g) in methanol (300 ml) and water (75 ml) were heated under reflux for 2 hours. The methanol was distilled off and the aqueous solution was acidified with dilute hydrochloric acid. The solid was collected, dried and crystallised from a mixture of ethyl acetate and light petroleum (b.p. 60°-80°). It had m.p. 146.5°-148.5° (d) (75%).

Provenance & Evidence