2-(Dimethylamino)ethanol → HCID 178422337, compound

HRID 1973369Notes

Reaction equation

HRID 1973369 reaction equation
[Cl:1][C:2]1[C:3]([C:14]([NH:16][C:17]2[NH:21][N:20]=[N:19][N:18]=2)=[O:15])=[N:4][C:5]2[C:10]([N:11]=1)=[CH:9][C:8]([CH3:12])=[C:7]([CH3:13])[CH:6]=2.[Na].[CH3:23][N:24]([CH3:28])[CH2:25][CH2:26][OH:27]>>[ClH:1].[CH3:23][N:24]([CH3:28])[CH2:25][CH2:26][O:27][C:2]1[C:3]([C:14]([NH:16][C:17]2[NH:21][N:20]=[N:19][N:18]=2)=[O:15])=[N:4][C:5]2[C:10]([N:11]=1)=[CH:9][C:8]([CH3:12])=[C:7]([CH3:13])[CH:6]=2

Participants

4

Reactant 3

HCID 79022-(Dimethylamino)ethanolHCID 5360545SodiumHCID 178422305HCID 178422305, compound

Product 1

HCID 178422337HCID 178422337, compound

Procedure

3-Chloro-6,7-dimethyl-N(1H-tetrazol-5-yl)-2-quinoxalinecarboxamide (Example 14) (3 g) was added to a solution of sodium (0.46 g) in 2-dimethylaminoethanol (20 ml) and the mixture was heated at 100° in an atmosphere of nitrogen for 5.5 hours and evaporated. The residue was dissolved in water and the solution was acidified with dilute hydrochloric acid. The solid was crystallised from dimethylformamide and had m.p. 247°-248° (d) (15%).

Workup

  1. temperaturethe mixture was heated at 100° in an atmosphere of nitrogen for 5.5 hours
  2. customevaporated
  3. dissolutionThe residue was dissolved in water
  4. customThe solid was crystallised from dimethylformamide

Sources & evidence

ORD record
ord-11bb059e4012435e987fb2afc6bca061
Source dataset
uspto-grants-1976_12
Patent number
US03997535

Reaction notes

Loading…