Sodium Carbonate → HCID 21491289, compound

HRID 1973380Notes

Reaction equation

HRID 1973380 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[N:6]=[C:5]([C:14]([O:16]CC)=[O:15])[C:4]1=[O:19])[CH3:2].C(=O)([O-])[O-].[Na+].[Na+]>CO.O>[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:13])[CH:11]=2)[N:6]=[C:5]([C:14]([OH:16])=[O:15])[C:4]1=[O:19])[CH3:2]

Participants

5

Reactant 2

HCID 10340Sodium CarbonateHCID 86734255Ethyl 4-ethyl-6-fluoro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylate

Product 1

HCID 21491289HCID 21491289, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

4-Ethyl-6-fluoro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylic acid, ethyl ester (8 g) and sodium carbonate (0.25 g) in methanol (20 ml) and water (10 ml) were heated under reflux for 2 hours. The methanol was distilled off and the aqueous solution was acidified with hydrochloric acid and the solid was collected. It had m.p. 162.5°-164° (39%).

Workup

  1. temperatureunder reflux for 2 hours
  2. distillationThe methanol was distilled off
  3. customthe solid was collected

Sources & evidence

ORD record
ord-3f662c70f4384580922093e7c61c580b
Source dataset
uspto-grants-1976_12
Patent number
US03997535

Reaction notes

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