Sodium Hydroxide → 62265-85-4

HRID 1973387Notes

Reaction equation

HRID 1973387 reaction equation
[Br-].[F:2][C:3]([F:22])([F:21])[C:4]1[CH:5]=[C:6]([CH:18]=[CH:19][CH:20]=1)[NH:7][C:8]1[CH:17]=[CH:16][N+:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[CH:9]=1.[OH-].[Na+]>O>[F:22][C:3]([F:2])([F:21])[C:4]1[CH:5]=[C:6]([N:7]=[C:8]2[CH:17]=[CH:16][N:15]3[C:10]([CH:11]=[CH:12][CH:13]=[CH:14]3)=[CH:9]2)[CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 124465292-[3-(Trifluoromethyl)anilino]quinolizin-5-ium bromide

Product 1

HCID 33019962265-85-4

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a suspension of 2-(3-trifluoromethylanilino)quinolizinium bromide (22 g., 0.060 mole) in H2O (400 ml) was added a solution of NaOH (25 g., 0.62 mole) in H2O (250 ml). The mixture was stirred at about 50° for 1 hour, then chilled and filtered. The yellow product weighed 17 g (97%). The sample was boiled in benzene, filtered and diluted with hexane. Evaporation of the solvent gave yellow crystals which melted at 134°-135°.

Workup

  1. temperaturechilled
  2. filtrationfiltered
  3. filtrationfiltered
  4. additiondiluted with hexane
  5. customEvaporation of the solvent
  6. customgave yellow crystals which melted at 134°-135°

Sources & evidence

ORD record
ord-8f9fc8fbaeb2447bafef26e5adac6538
Source dataset
uspto-grants-1976_12
Patent number
US03997547

Reaction notes

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