HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → (2E)-N-[3-(Trifluoromethyl)phenyl]-2H-quinolizin-2-imine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-[3-(Trifluoromethyl)anilino]quinolizin-5-ium bromide | HCID 12446529 | — |
| Solvent | Water | HCID 962 | — |
| Product | (2E)-N-[3-(Trifluoromethyl)phenyl]-2H-quinolizin-2-imine | HCID 330199 | — |
Reaction Steps
To a suspension of 2-(3-trifluoromethylanilino)quinolizinium bromide (22 g., 0.060 mole) in H2O (400 ml) was added a solution of NaOH (25 g., 0.62 mole) in H2O (250 ml). The mixture was stirred at about 50° for 1 hour, then chilled and filtered. The yellow product weighed 17 g (97%). The sample was boiled in benzene, filtered and diluted with hexane. Evaporation of the solvent gave yellow crystals which melted at 134°-135°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03997547 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-8f9fc8fbaeb2447bafef26e5adac6538 |
| Source note | uspto-grants-1976_12 |