HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1973435Generated: November 1, 2026
Sodium Hydroxide → N-isopropyl-N-(3,4-methylenedioxyphenyl)thiourea
https://huagongshe.com/reaction/1973435
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | N-isopropyl-N-(3,4-methylenedioxyphenyl)-N'-benzoyl thiourea | HCID 12789467 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-isopropyl-N-(3,4-methylenedioxyphenyl)thiourea | HCID 12789468 | — |
Reaction Steps
To a stirred solution consisting of 45 ml. of dioxane and 200 ml. of water is added 27 grams of sodium hydroxide and the whole stirred until complete solution takes place. To this solution is added 17 grams of N-isopropyl-N-(3,4-methylenedioxyphenyl)-N'-benzoyl thiourea. The resulting mixture is heated to reflux for 48 hours and then cooled to 15°C. The resulting white solid is crystallized from benzene to obtain N-isopropyl-N-(3,4-methylenedioxyphenyl)-thiourea melting at 149°-151°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03997564 |
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| Source dataset | uspto-grants-1976_12 |
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| ORD ID | ord-314d0f9e9c354830a9f0c12ac0e3f59e |
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| Source note | uspto-grants-1976_12 |
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