反应详情

A mixture of 17.0 parts of 1-(2-chloroethyl)-2-methyl-5-nitroimidazole, 18.0 parts of potassium phthalimide, and 2.0 parts of potassium iodide in 240 parts of dimethylformamide is heated in a boiling water bath for 3 hours with stirring. Stirring is then continued for 16 hours at room temperature. The resulting brown mixture is diluted with 870 parts of toluene and the toluene solution is washed with several portions of water. The toluene solution is dried over sodium sulfate and the solvent is evaporated to leave a residue which is digested with cold alcohol. The alcohol solution is then cooled and the precipitate which forms is separated by filtration and recrystallized from ethanol to give N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]phthalimide melting at about 177° C. This compound has the following formula ##STR6##

1. temperatureis heated in a boiling water bath for 3 hours
2. stirringStirring
3. washthe toluene solution is washed with several portions of water
4. dry with materialThe toluene solution is dried over sodium sulfate
5. customthe solvent is evaporated
6. customto leave a residue which
7. customthe precipitate which forms is separated by filtration
8. customrecrystallized from ethanol