反应详情

A one-liter flask containing 92 parts of 4-bromo-2,5-diisopropylbenzenesulfonamide, 30 parts of cuprous cyanide, and 250 parts N-methylpyrrolidone is heated at 190°-200° for 2 hours. The reaction mixture is cooled to 100° and is then poured into 1000 parts water. The precipitated material is filtered. It is heated for 2 hours near reflux with 1000 parts water and 30 parts sodium cyanide. The reaction is cooled and the precipitate filtered to obtain 60 parts 4-cyano-2,5-diisopropylbenzenesulfonamide. The solid can be recrystallized from methanol, and then exhibits a m.p. of 200°-202°.

1. temperatureis heated at 190°-200° for 2 hours
2. temperatureThe reaction mixture is cooled to 100°
3. filtrationThe precipitated material is filtered
4. temperatureIt is heated for 2 hours
5. temperaturenear reflux with 1000 parts water and 30 parts sodium cyanide
6. temperatureThe reaction is cooled
7. filtrationthe precipitate filtered