Hydrochloric Acid → HCID 22795129, compound

HRID 1973639Notes

Reaction equation

HRID 1973639 reaction equation
[C:1]([O:20][C@@H:21]1[C@@H:25]([CH2:26][OH:27])[O:24][C@@H:23]([N:28]2[CH:35]=[CH:34][C:32]([NH2:33])=[N:31][C:29]2=[O:30])[C@H:22]1[OH:36])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[ClH:37]>C(O)C>[ClH:37].[C:1]([O:20][C@@H:21]1[C@@H:25]([CH2:26][OH:27])[O:24][C@@H:23]([N:28]2[CH:35]=[CH:34][C:32]([NH2:33])=[N:31][C:29]2=[O:30])[C@H:22]1[OH:36])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22795073HCID 22795073, compound

Product 1

HCID 22795129HCID 22795129, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In this example a solution of 5.09 g (10 mmol) of 1-(3'-O-stearoyl-β-D-arabinofuranosyl)-cytosine in warm ethanol is treated with a 10% excess (11 mmoles) methanolic hydrogen chloride. Crystallization of the resulting hydrochloride is completed by addition of ether and the resulting product is recrystallized from ethanol giving 1-(3'-O-stearoyl-β-D-arabinofuranosyl)cytosine hydrochloride.

Workup

  1. customCrystallization of the resulting hydrochloride
  2. additionis completed by addition of ether
  3. customthe resulting product is recrystallized from ethanol

Sources & evidence

ORD record
ord-d8b70c6b95984300879862e9bd76bb48
Source dataset
uspto-grants-1976_12
Patent number
US03998807

Reaction notes

Loading…