Thionyl Chloride → [(2,2,2-Trifluoroethyl)sulfanyl]acetyl chloride

HRID 1973641Notes

Reaction equation

HRID 1973641 reaction equation
S(Cl)([Cl:3])=O.[F:5][C:6]([F:14])([F:13])[CH2:7][S:8][CH2:9][C:10](O)=[O:11]>>[F:5][C:6]([F:14])([F:13])[CH2:7][S:8][CH2:9][C:10]([Cl:3])=[O:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 167908082-[(2,2,2-Trifluoroethyl)sulfanyl]acetic acid

Product 1

HCID 21816785[(2,2,2-Trifluoroethyl)sulfanyl]acetyl chloride

Procedure

Thionyl chloride (21.9 g, 184 mmol) and trifluoroethylmercaptoacetic acid (15.9 g; 91 mmol) were stirred together overnight. The excess reagent was removed in vacuo and the product was distilled; bp 62°-68°/20 mm.

Workup

  1. customThe excess reagent was removed in vacuo
  2. distillationthe product was distilled

Sources & evidence

ORD record
ord-a7f62426647e4b4db636c8e32915a959
Source dataset
uspto-grants-1976_12
Patent number
US03998818

Reaction notes

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