HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-[3,3-Diphenyl-3-(pyridin-2-yl)propyl]-2-azabicyclo[2.2.2]octane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 2-(2-Chloroethyl)-2-azabicyclo[2.2.2]octane | HCID 12612325 | — |
| Reactant | 2-(2-Phenylbenzyl) pyridine | HCID 54388156 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 2-[3,3-Diphenyl-3-(pyridin-2-yl)propyl]-2-azabicyclo[2.2.2]octane | HCID 20356903 | — |
Reaction Steps
This method represents a modification of methods described by Martensson and Nilson, Acta Chem. Scand. 19 (3), 711-12 (1965) -- CA-63-6968h. Thus, 1 part of 2-(2-phenylbenzyl) pyridine is reacted with 1 part of n-Butyl lithium in tetrahydrofuran at -70° C. and then reacted with 1 part of 2-(2-chloroethyl)-2-azabicyclo[2.2.2 ]octane to provide 2-[3,3-diphenyl-3-(2-pyridyl)propyl]-2-azabicyclo[2.2.2 ]octane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03998832 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-6c4a2b04735e4f758cd558d332e4bcc1 |
| Source note | uspto-grants-1976_12 |