反应详情

This method represents a modification of methods described by Martensson and Nilson, Acta Chem. Scand. 19 (3), 711-12 (1965) -- CA-63-6968h. Thus, 1 part of 2-(2-phenylbenzyl) pyridine is reacted with 1 part of n-Butyl lithium in tetrahydrofuran at -70° C. and then reacted with 1 part of 2-(2-chloroethyl)-2-azabicyclo[2.2.2 ]octane to provide 2-[3,3-diphenyl-3-(2-pyridyl)propyl]-2-azabicyclo[2.2.2 ]octane.

1. customCA-63-6968h