2,2-Dimethyl-1-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]propan-1-one → 1-(4-Acetylphenyl)-2,2-dimethylpropan-1-one

HRID 1973700Notes

Reaction equation

HRID 1973700 reaction equation
[CH3:1][C:2]1([C:7]2[CH:12]=[CH:11][C:10]([C:13](=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:9][CH:8]=2)OCC[O:3]1>Cl>[C:2]([C:7]1[CH:12]=[CH:11][C:10]([C:13](=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:9][CH:8]=1)(=[O:3])[CH3:1]

Participants

3

Reactant 1

HCID 545049922,2-Dimethyl-1-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]propan-1-one

Product 1

HCID 214903651-(4-Acetylphenyl)-2,2-dimethylpropan-1-one

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 70.3 g. (0.284 mole) 4'-(2-methyl-2-dioxolanyl) pivalophenone and 700 ml of 2N hydrochloric acid is refluxed for 18 hours. The resulting solution is cooled, extracted with ether, the ether washed with salt water, dried, evaporated and the resulting residue is distilled at 88°-86° C mm Hg to give 4'-acetylpivalophenone.

Workup

  1. additionA mixture of 70.3 g
  2. temperatureThe resulting solution is cooled
  3. extractionextracted with ether
  4. washthe ether washed with salt water
  5. customdried
  6. customevaporated
  7. distillationthe resulting residue is distilled at 88°-86° C mm Hg

Sources & evidence

ORD record
ord-c5b932264866464a867b27832447733b
Source dataset
uspto-grants-1976_12
Patent number
US03998850

Reaction notes

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