Hydrochloric Acid → 2'-Methoxy-4'acetylpivalophenone

HRID 1973701Notes

Reaction equation

[CH3:1][C:2]1([C:7]2[CH:12]=[CH:11][C:10]([C:13](=[O:18])[C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:9][CH:8]=2)[O:6]CCO1.[CH3:19][O:20]C1(CC(C)(C)C(C2C=CC=CC=2)=O)OCCO1.Cl>>[CH3:19][O:20][C:9]1[CH:8]=[C:7]([C:2](=[O:6])[CH3:1])[CH:12]=[CH:11][C:10]=1[C:13](=[O:18])[C:14]([CH3:15])([CH3:16])[CH3:17]

Participants

Reactant 3

HCID 313Hydrochloric Acid2×

HCID 53904914(2-Methoxy-2-dioxolanyl)pivalophenone

HCID 545049922,2-Dimethyl-1-[4-(2-methyl-1,3-dioxolan-2-yl)phenyl]propan-1-one

Product 1

HCID 214903642'-Methoxy-4'acetylpivalophenone

Procedure

Again following the above procedure and using in place of 4'-(2-methyl-2-dioxolanyl)pivalophenone an equivalent amount of (2-methoxy-2-dioxolanyl)pivalophenone in the presence of a dilute hydrochloric acid in place of concentrated hydrochloric acid, there is obtained 2'-methoxy-4'acetylpivalophenone.

Sources & evidence

ORD record: ord-e35c844417a14fb79ddafcdff21f6464
Source dataset: uspto-grants-1976_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03998850

Reaction notes

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