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HRID1973721

反应详情

EQUATION

反应方程式

HRID 1973721 的结构方程式

REACTANTS

反应物

4
结构：CCO
HCID702

Ethanol

C2H6O

结构：O
HCID962

Water

H2O

结构：O=C([O-])O.[K+]
HCID516893

Potassium bicarbonate

CHKO3

结构：C=CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID86734286

未命名化合物

PRODUCTS

生成物

1
结构：CCOCCC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID86734288

未命名化合物

PROCEDURE

实验过程

3α-Hydroxy-21-methylene-5α-pregnane11,20 -dione (250 mg) was dissolved in ethanol (50 ml) and potassium bicarbonate solution (10%; 3 ml) added to the refluxing solution. After 3/4 hour the mixture was poured into water, and extracted into ether. The extract was washed with water, dried (Na2SO4) and evaporated to a white solid (190 mg) which was recrystallised from ether to give title compound (120 mg) m.p. 126°-129.5° C [α]D + 87.5° (c, 1.03).

WORKUP

后处理

  1. extractionextracted into ether
  2. washThe extract was washed with water
  3. dry with materialdried (Na2SO4)
  4. customevaporated to a white solid (190 mg) which
  5. customwas recrystallised from ether