Ethanol → 21-Ethoxymethyl-3alpha-hydroxy-5alpha-pregnane-11,20-dione

Participants

Reaction Steps

3α-Hydroxy-21-methylene-5α-pregnane11,20 -dione (250 mg) was dissolved in ethanol (50 ml) and potassium bicarbonate solution (10%; 3 ml) added to the refluxing solution. After 3/4 hour the mixture was poured into water, and extracted into ether. The extract was washed with water, dried (Na2SO4) and evaporated to a white solid (190 mg) which was recrystallised from ether to give title compound (120 mg) m.p. 126°-129.5° C [α]D + 87.5° (c, 1.03).

Provenance & Evidence