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HRID1973722

反应详情

EQUATION

反应方程式

HRID 1973722 的结构方程式

REACTANTS

反应物

1
结构：C=C(CN1CCOCC1)C(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID86734289

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)C(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C
HCID22795167

未命名化合物

收率 44.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

3α-Hydroxy-21-methylene-21-morpholinomethyl-5α-pregnane-11,20-dione (500 mg) was hydrogenated over 10% palladium on carbon (50 mg) in ethyl acetate. The catalyst was filtered off and the filtrate evaporated to a white foam. The foam was purified by preparative t.l.c. (ethyl acetate/petrol) to give title compound (180 mg) as a white foam [α]D + 133° (c, 1.02).

WORKUP

后处理

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated to a white foam
  3. customThe foam was purified by preparative t.l.c