反应详情

To a stirred mixture of 3.25 parts of 4-(methoxymethyl)-N-phenyl-1-(2-phenylethyl)-4-piperidinamine and 36 parts of dry methylbenzene is added a mixture of 1.25 parts of cyclopropanecarbonyl chloride and 9 parts of dry methylbenzene at room temperature. The whole is stirred and refluxed for 3 hours. The reaction mixture is filtered hot and upon cooling, the product is allowed to crystallize from the filtrate. It is filtered off, washed with 2,2'-oxybispropane and dried, yielding N-[4-(methoxymethyl)-1-(2-phenylethyl)-4-piperidinyl]-N-phenylcyclopropanecarboxamide hydrochloride; mp. 178.6° C.

1. additionis added
2. temperaturerefluxed for 3 hours
3. filtrationThe reaction mixture is filtered hot
4. temperatureupon cooling
5. customto crystallize from the filtrate
6. filtrationIt is filtered off
7. washwashed with 2,2'-oxybispropane
8. customdried