Thionyl Chloride → HCID 732021, compound

HRID 1973873Notes

Reaction equation

HRID 1973873 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:17][C:16](=O)[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[CH:5]=[CH:6][CH:7]=1.S(Cl)([Cl:21])=O>CN(C)C=O>[Cl:21][C:16]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:17]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 135408290HCID 135408290, compound

Product 1

HCID 732021HCID 732021, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 5.5 g of 2-(3-chlorophenyl)quinazolin-4(3H)-one and 40 ml of thionyl chloride was treated as described in Example I with 1.57 g of dimethylformamide to give, after recrystallization from cyclohexane, 4.4 g of white 4-chloro-2-(3-chlorophenyl)quinazoline, m.p. 157°-158.5°.

Workup

  1. additionwas treated
  2. customto give
  3. customafter recrystallization from cyclohexane, 4.4 g of white 4-chloro-2-(3-chlorophenyl)quinazoline, m.p. 157°-158.5°

Sources & evidence

ORD record
ord-3ff078201ad84a008a3776d350d4a46a
Source dataset
uspto-grants-1976_12
Patent number
US03998951

Reaction notes

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