Methane → HCID 21490747, compound

HRID 1973887Notes

Reaction equation

HRID 1973887 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([C:13]([OH:15])=O)[C:5](=[CH:10][C:11]=1[CH3:12])[CH2:6][C:7]([OH:9])=O.[CH:16]([NH2:19])([CH3:18])[CH3:17].C>C(O)C>[CH:16]([N:19]1[C:7](=[O:9])[CH2:6][C:5]2[C:4](=[CH:3][C:2]([CH3:1])=[C:11]([CH3:12])[CH:10]=2)[C:13]1=[O:15])([CH3:18])[CH3:17]

Participants

5

Reactant 3

HCID 297MethaneHCID 6363IsopropylamineHCID 21490818HCID 21490818, compound

Product 1

HCID 21490747HCID 21490747, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4,5-dimethylhomophthalic acid (104 g., 0.5 mole) and isopropylamine (59 g., 1 mole) is heated by an oil bath until molten for 90 minutes. The hot mixture is then poured into 600 ml. of ethanol, treated with carbon black and filtered. The mixture is concentrated to about 300 ml. and slowly cooled to room temperature. 2-Isopropyl-6,7-dimethylisoquinoline-1,3(2H,4H)-dione precipitates and is collected by filtration.

Workup

  1. temperatureis heated by an oil bath until molten for 90 minutes
  2. additionThe hot mixture is then poured into 600 ml
  3. filtrationfiltered
  4. concentrationThe mixture is concentrated to about 300 ml
  5. custom2-Isopropyl-6,7-dimethylisoquinoline-1,3(2H,4H)-dione precipitates
  6. filtrationis collected by filtration

Sources & evidence

ORD record
ord-c6d687b01fe5471d80c75f530f4b0605
Source dataset
uspto-grants-1976_12
Patent number
US03998954

Reaction notes

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