Methane → HCID 21490831, compound

HRID 1973890Notes

Reaction equation

HRID 1973890 reaction equation
[C:1]([OH:13])(=O)[CH2:2][CH:3]1[CH:11]=[CH:10][CH2:9][CH2:8][CH:4]1[C:5]([OH:7])=O.[CH:14]([NH2:17])([CH3:16])[CH3:15].C>C(O)C>[CH:14]([N:17]1[C:1](=[O:13])[CH2:2][C:3]2[CH2:11][CH2:10][CH2:9][CH2:8][C:4]=2[C:5]1=[O:7])([CH3:16])[CH3:15]

Participants

5

Reactant 3

HCID 297MethaneHCID 6363IsopropylamineHCID 131710580HCID 131710580, compound

Product 1

HCID 21490831HCID 21490831, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of tetrahydrohomophthalic acid (92 g., 0.5 mole) and isopropylamine (59 g., 1 mole) is heated by an oil bath until molten for 90 minutes. The hot mixture is then poured into 600 ml. of ethanol, treated with carbon black and filtered. The mixture is concentrated to about 300 ml. and slowly cooled to room temperature. 2-Isopropylisoquinoline-1,3(2H,4H)-dione precipitates and is collected by filtration.

Workup

  1. temperatureis heated by an oil bath until molten for 90 minutes
  2. additionThe hot mixture is then poured into 600 ml
  3. filtrationfiltered
  4. concentrationThe mixture is concentrated to about 300 ml
  5. custom2-Isopropylisoquinoline-1,3(2H,4H)-dione precipitates
  6. filtrationis collected by filtration

Sources & evidence

ORD record
ord-4aa7799fd86e4136903dd0000f01f3b5
Source dataset
uspto-grants-1976_12
Patent number
US03998954

Reaction notes

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