HCID 21490882, compound → HCID 21490887, compound

HRID 1973893Notes

Reaction equation

HRID 1973893 reaction equation
C([O:4][CH2:5][C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([CH2:13][CH2:14][CH2:15][CH3:16])=[C:8]([Cl:17])[N:7]=1)(=O)C>Cl>[OH:4][CH2:5][C:6]1[CH:11]=[C:10]([Cl:12])[C:9]([CH2:13][CH2:14][CH2:15][CH3:16])=[C:8]([Cl:17])[N:7]=1

Participants

3

Reactant 1

HCID 21490882HCID 21490882, compound

Product 1

HCID 21490887HCID 21490887, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

40 g of 2-acetoxymethyl-4,6-dichloro-5-n-butyl-pyridine in 200 ml of 6 N hydrochloric acid are boiled for 15 hours under reflux. Thereafter the mixture is evaporated to dryness. The residue is taken up in chloroform and extracted by shaking with aqueous potassium carbonate solution. The chloroform solution is dried and evaporated. Fractional distillation yields 2-hydroxymethyl-4,6-dichloro-5-n-butyl-pyridine of boiling point 150°-160° (0.1 mm Hg).

Workup

  1. temperatureunder reflux
  2. customThereafter the mixture is evaporated to dryness
  3. extractionextracted
  4. dry with materialThe chloroform solution is dried
  5. customevaporated
  6. distillationFractional distillation

Sources & evidence

ORD record
ord-ddf36dc61d3843818b0cdcfe50d241a8
Source dataset
uspto-grants-1976_12
Patent number
US03998955

Reaction notes

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