Hydroxyamine hydrochloride → HCID 86733921, compound

HRID 1973994Notes

Reaction equation

HRID 1973994 reaction equation
[F:1][CH:2]([F:22])[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9]([CH:14]([CH:19]([F:21])[F:20])[C:15](OC)=[O:16])[CH:8]=[CH:7]2.C[O-].[Na+].Cl.[NH2:27][OH:28]>CO>[F:1][CH:2]([F:22])[O:3][C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][CH:13]=1)[CH:10]=[C:9]([CH:14]([CH:19]([F:21])[F:20])[C:15]([NH:27][OH:28])=[O:16])[CH:8]=[CH:7]2

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 10942334Sodium MethoxideHCID 70591758HCID 70591758, compound

Product 1

HCID 86733921HCID 86733921, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 32 g. of methyl 6-difluoromethoxy-2-naphthyl-α-difluoromethylacetate, 10 g. of sodium methoxide, 14 g. of hydroxylamine hydrochloride, and 500 ml. of methanol are allowed to stand for 16 hours. The mixture is then filtered and evaporated. The residue is neutralized by the addition of aqueous 1N hydrochloric acid and extracted by ether. The ether solution is then washed with water, dried, and evaporated to afford 6-difluoromethoxy-2-naphthyl-α-difluoromethyl acethydroxamic acid.

Workup

  1. additionA mixture of 32 g
  2. filtrationThe mixture is then filtered
  3. customevaporated
  4. additionThe residue is neutralized by the addition of aqueous 1N hydrochloric acid
  5. extractionextracted by ether
  6. washThe ether solution is then washed with water
  7. customdried
  8. customevaporated

Sources & evidence

ORD record
ord-0a75eff8ee264e66ae474b7e4c9f0e23
Source dataset
uspto-grants-1976_12
Patent number
US03998966

Reaction notes

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