Sodium Iodide → HCID 21488616, compound

Participants

Reaction Steps

5-Chloro-2-[3-(chloromethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenone (346 mg. 0.001 mole) is added to a stirred solution of sodium iodide (300 mg., 0.002 mole) in acetone, and the resulting mixture is stirred at ambient temperature for 6 hours 54 minutes and poured into ice water. This mixture is extracted with chloroform. The extract is washed with brine, dried and concentrated. The residue is crystallized from methylene chloride-ethyl acetate to give: 0.227 g. of melting point 185.5°-192° (decomposition) of 5-chloro-2-[3-(iodomethyl)-5-methyl-4H-1,2,4-triazol-4-triazol-4-yl]benzophenone. The analytical sample has a melting point of 185°-200° C. (decomposition).

Provenance & Evidence