Sodium Iodide → HCID 21488616, compound

HRID 1974054Notes

Reaction equation

HRID 1974054 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH3:21])=[N:19][N:18]=[C:17]2[CH2:22]Cl)=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8].[I-:24].[Na+]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH3:21])=[N:19][N:18]=[C:17]2[CH2:22][I:24])=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 21488575(5-Chloro-2-(3-(chloromethyl)-5-methyl-4H-1,2,4-triazol-4-yl)phenyl)(phenyl)methanone

Product 1

HCID 21488616HCID 21488616, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5-Chloro-2-[3-(chloromethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenone (346 mg. 0.001 mole) is added to a stirred solution of sodium iodide (300 mg., 0.002 mole) in acetone, and the resulting mixture is stirred at ambient temperature for 6 hours 54 minutes and poured into ice water. This mixture is extracted with chloroform. The extract is washed with brine, dried and concentrated. The residue is crystallized from methylene chloride-ethyl acetate to give: 0.227 g. of melting point 185.5°-192° (decomposition) of 5-chloro-2-[3-(iodomethyl)-5-methyl-4H-1,2,4-triazol-4-triazol-4-yl]benzophenone. The analytical sample has a melting point of 185°-200° C. (decomposition).

Workup

  1. extractionThis mixture is extracted with chloroform
  2. washThe extract is washed with brine
  3. customdried
  4. concentrationconcentrated
  5. customThe residue is crystallized from methylene chloride-ethyl acetate
  6. customto give

Sources & evidence

ORD record
ord-98c3a9aa6be74a24aeb9165e48e2e62f
Source dataset
uspto-grants-1976_12
Patent number
US04000151

Reaction notes

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