Ammonia → 8-Chloro-6-(2,6-difluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

HRID 1974059Notes

Reaction equation

HRID 1974059 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:18]2[C:22]([CH3:23])=[N:21][N:20]=[C:19]2[CH2:24]Br)=[C:6]([CH:17]=1)[C:7]([C:9]1[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:10]=1[F:16])=O.[NH3:26]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:18]3[C:22]([CH3:23])=[N:21][N:20]=[C:19]3[CH2:24][N:26]=[C:7]([C:9]3[C:14]([F:15])=[CH:13][CH:12]=[CH:11][C:10]=3[F:16])[C:6]=2[CH:17]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 21488608HCID 21488608, compound

Product 1

HCID 214885888-Chloro-6-(2,6-difluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the manner given in Example 10, 5-chloro-2',6'-difluoro-2-[3-(bromomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenone is reacted with a saturated solution of ammonia in methanol to give 8-chloro-1-methyl-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine of melting point 126°-127° C. (decomposition).

Sources & evidence

ORD record
ord-8fcbdcd98fba4299bc083b00e8864a96
Source dataset
uspto-grants-1976_12
Patent number
US04000151

Reaction notes

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