HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 8-Chloro-6-(2,6-difluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 21488608 | HCID 21488608 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 8-Chloro-6-(2,6-difluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine | HCID 21488588 | — |
Reaction Steps
In the manner given in Example 10, 5-chloro-2',6'-difluoro-2-[3-(bromomethyl)-5-methyl-4H-1,2,4-triazol-4-yl]benzophenone is reacted with a saturated solution of ammonia in methanol to give 8-chloro-1-methyl-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine of melting point 126°-127° C. (decomposition).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04000151 |
| Source dataset | uspto-grants-1976_12 |
| ORD ID | ord-8fcbdcd98fba4299bc083b00e8864a96 |
| Source note | uspto-grants-1976_12 |