7-Chloro-5-(2-chlorophenyl)-1-methyl-[1,2,4]triazolo[4,3-A]quinoline → (5-Chloro-2-(3-methyl-4H-1,2,4-triazol-4-yl)phenyl)(2-chlorophenyl)methanone

HRID 1974062Notes

Reaction equation

HRID 1974062 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[C:12](C)=[N:13][N:14]=[C:7]1[CH:6]=[C:5]2[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[Cl:22].I([O-])(=O)(=O)=[O:24].[Na+]>[Ru](=O)=O>[Cl:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[C:5](=[O:24])[C:4]1[CH:3]=[C:2]([Cl:1])[CH:11]=[CH:10][C:9]=1[N:8]1[CH:12]=[N:13][N:14]=[C:7]1[CH3:6]

Participants

4

Reactant 2

HCID 214885877-Chloro-5-(2-chlorophenyl)-1-methyl-[1,2,4]triazolo[4,3-A]quinolineHCID 23667635Sodium periodate

Product 1

HCID 626552(5-Chloro-2-(3-methyl-4H-1,2,4-triazol-4-yl)phenyl)(2-chlorophenyl)methanone

Reagents, catalysts & solvents 1

HCID 82848Ruthenium dioxideCatalyst

Procedure

In the manner given in Example 3, 7-chloro-1-methyl-5-(o-chlorophenyl)-s-triazolo[4,3-a]quinoline is oxidized at low temperature with sodium periodate and ruthenium dioxide to give 2',5-dichloro-2-(3-methyl-4H-1,2,4-triazol-4-yl)benzophenone of melting point 147.5°-148.5° C.

Sources & evidence

ORD record
ord-d34669a465af47c68897b3bf314e1a9c
Source dataset
uspto-grants-1976_12
Patent number
US04000151

Reaction notes

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