Ethyl 3-furoate → N-{2-[2-(1-Methylpiperidin-2-yl)ethyl]phenyl}furan-3-carboxamide
Reaction equation
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([O:8]CC)=O)=[CH:2]1.[NH2:11][C:12]1[CH:26]=[CH:25][CH:24]=[CH:23][C:13]=1[CH2:14][CH2:15][CH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][N:17]1[CH3:22]>>[CH3:22][N:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH:16]1[CH2:15][CH2:14][C:13]1[CH:23]=[CH:24][CH:25]=[CH:26][C:12]=1[NH:11][C:6]([C:3]1[CH:4]=[CH:5][O:1][CH:2]=1)=[O:8]Participants
3
Procedure
Reaction of ethyl furan-3-carboxylate prepared by the method of Boyd et al, Synthesis, 545, (Oct. 1971) with 2-(2-amino-phenethyl)-1-methylpiperidine according to the procedure of Example 115 provides 2'-[2-(1-methyl-2-piperidyl)ethyl]-3-furancarboxanilide, m.p. 114.5° - 115.5° C. (corr.), from isopropyl ether and then ethyl acetate.
Sources & evidence
- ORD record
- ord-81e8449a8a184f09a3cd4231a7fb1866
- Source dataset
- uspto-grants-1976_12
- Patent number
- US04000143
Reaction notes
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