反应详情

A stirred mixture of 2,6-dichloro-4-phenylquinoline (2.7 g., 0.01 mole) and hydrazine hydrate (6.8 g.) is refluxed under nitrogen for 1 hour and concentrated in vacuo. The residue is suspended in warm water, and the solid is collected by filtration, dried and recrystallized from ethyl acetate-Skellysolve B hexanes to give 1.81 g. (67% yield) of 6-chloro-2-hydrazino-4-phenylquinoline of melting point 156.5°-157° C.

1. temperatureis refluxed under nitrogen for 1 hour
2. concentrationconcentrated in vacuo
3. filtrationthe solid is collected by filtration
4. customdried
5. customrecrystallized from ethyl acetate-Skellysolve B hexanes
6. customto give 1.81 g