Triethyl orthoacetate → HCID 21488574, compound

HRID 1974128Notes

Reaction equation

HRID 1974128 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][NH2:13])[CH:6]=[C:5]2[C:14]1[C:19]([F:20])=[CH:18][CH:17]=[CH:16][C:15]=1[F:21].[C:22](OCC)(OCC)(OCC)[CH3:23]>C1(C)C(C)=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]1[C:22]([CH3:23])=[N:13][N:12]=[C:7]1[CH:6]=[C:5]2[C:14]1[C:15]([F:21])=[CH:16][CH:17]=[CH:18][C:19]=1[F:20]

Participants

4

Reactant 2

HCID 66221Triethyl orthoacetateHCID 21488596HCID 21488596, compound

Product 1

HCID 21488574HCID 21488574, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

In the manner given in Example 2, 6-chloro-4-(2,6-difluorophenyl)-2-hydrazinoquinoline and triethyl orthoacetate are refluxed in xylene to give 7-chloro-1-methyl-5-(2,6-difluorophenyl)-s-triazolo[4,3-a]quinoline.

Sources & evidence

ORD record
ord-41fda63eaee34bf2acc2375082c96973
Source dataset
uspto-grants-1976_12
Patent number
US04000153

Reaction notes

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